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Etomidate ppt

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AMIDATE (Etomidate Injection, USP) is a sterile, nonpyrogenic solution. Each milliliter contains etomidate, 2 mg, propylene glycol 35% v/v. The pH is 6.0 (4.0 to 7.0). It is intended for the induction of general anesthesia by intravenous injection. The drug etomidate is chemically identified as (R)-(+)-ethyl-1-(1-phenylethyl)-1H-imidazole-5 Upchurch CP et al. Comparison of etomidate and ketamine for induction during rapid sequence intubation of adult trauma patients. Ann Emerg Med 2017; 69: 24-33

Etomidate (USAN, INN, BAN; marketed as Amidate) is a short-acting intravenous anaesthetic agent used for the induction of general anaesthesia and sedation for short procedures such as reduction of dislocated joints, tracheal intubation, cardioversion and electroconvulsive therapy AMIDATE - Etomidate Injection, Solution is a solution containing etomidate, an intravenous anesthetic used for the induction of general anesthesia. In the workplace, this material should be considered potentially irritating to the eyes and respiratory tract. Based on clinical use, possible target organs include the central nervous system Etomidate 20 mg IV Succinylcholine 100 mg IV WAIT 45 S Intubation RSI, rapid‐sequence intubation; VC, vital capacity; IV, intravenous. RSI - patient with increased ICP (70 kg) 100% oxygen (3 min or 8VC breaths Lidocaine 100 mg IV Vecuronium 1 mg IV Fentanyl 200 μg IV WAIT 3 MI

Ppt. HAD 1. แนวทางการจัดการยาที่มีความเสี่ยงสูง ( HIGH ALERT DRUGS ) ในโรงพยาบาล นพ.ปรัชญา ศรีสว่าง 15-Aug-14 1 esmoron, succinyl, siccum, thiopental, etomidate ยาที่มี therapeutic index แคบ. ETOMIDATE [ R -1- (1-ethylphenyl)imidazole-5-ethyl ester] (fig. 1) is a unique drug used for induction of general anesthesia and sedation Etomidate, an imidazole derivative, is a sedative that is commonly used for PSA. The use of etomidate for rapid sequence intubation is discussed elsewhere. For PSA in adults, etomidate is given Pharmacology and toxicity of adrenal enzyme inhibitors and adrenolytic agent

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  1. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 1 Apr 2021), Cerner Multum™ (updated 5 Apr 2021), ASHP (updated 6 Apr 2021.
  2. Etomidate crosses the placenta (Esener 1992; Gregory 1991). Based on animal data, repeated or prolonged use of general anesthetic and sedation medications that block N-methyl-D-aspartate receptors and/or potentiate GABA activity may affect brain development
  3. 14 ETOMIDATE Ruth et al. • ETOMIDATE AND PROCEDURAL SEDATION Figure 1. Modified Aldrete PAR score. Based on references 7-10 (see reference list). phase study encompassing a pilot and feasibility evaluation of ED patients. The first phase was a retrospective, descriptive series of a convenience sample of ED patients receiving etomidate for.
  4. istered after fentanyl was associated with effective sedation, successful procedural completion, and readily managed respiratory adverse events in children

As with ketamine or barbiturates, etomidate transiently lowers cerebral blood flow by 20-30% and slightly reduces intracranial and intraocular pressure. It has no analgesic properties. Onset of action is 5-30 seconds with peak action at 1 minute. Etomidate has a duration of 2-10 minutes depending on the dose Etomidate has been shown to be safe for procedural sedation in the pediatric population. Its' benefits include a favorable hemodynamic profile and short duration of action. Consider how much time you anticipate the procedure to last, as Etomidate is best suited for short procedures Etomidate is used less frequently in sepsis patients than nonsepsis patients, with ketamine being the most frequently used alternative. Ketamine was associated with more postprocedural hypotension than etomidate. Future clinical trials are needed to determine the optimal induction agent in patients Etomidate produces clinical responses such as hypnosis, elevations in arterial carbon dioxide tension, reduced cortisol plasma levels, and, similar to thiopental, a transient 20—30% decrease in cerebral blood flow. This reduction appears to be uniform in the absence of space occupying lesions. Etomidate induction is usually followed by a. World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Winner of the Standing Ovation Award for Best PowerPoint Templates from Presentations Magazine. They'll give your presentations a professional, memorable appearance - the kind of sophisticated look that today's audiences expect

Myoclonus associated with etomidate for ED procedural sedation and analgesia. Am J Emerg Med. 2003;21:556-558. ↑ Sener S, Eken C, Schultz CH, Serinken M, Ozsarac M. Ketamine with and without midazolam for emergency department sedation in adults: a randomized controlled trial. Ann Emerg Med. 2011 Feb;57(2):109-114.e Etomidate is an intravenous anesthetic agent typically used for the induction of general anesthesia, with the advantage of maintenance of hemodynamic stability. Etomidate's hypnotic effects are believed to result from enhancement of γ-aminobutyric acid type A (GABA-A) receptor function

The mean difference between etomidate and propofol in the MAP-time integral below baseline was 2244 mm Hg s (95% confidence interval, 581-3906; P =0.009), representing a 34% greater reduction with propofol Etomidate (Amidate) clearance ranges from 18-25 ml/kg/min. Etomidate clearance can be compared to that of thiopental (Pentothal) which is a clearance of about 3.5 ml/kg/min. V d is large, consistent with a relatively lipophilic compound which gains access to many compartments Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet. 2009 Jul 25;374(9686):293-300. Leeuwenburg T. Airway Management of the Critically Ill Patient: Modifications of Traditional Rapid Sequence Induction and Intubation Synthesized by Lundy in 1932 / 1934 Pearl Harbour as sole agent killed many Ultra-short acting thiobarbiturate Sulphur analogue of pentobarbitone Yellow powder, garlic smell, bitter taste Preparation: 2,5% = 25mg/ml (500mg/20ml) 85% plasma protein binding (albumin) 10-15% per hour metabolised by liver 2013/05/28 16 STP Pentothal

etomidate can In the human liver cells, the researchers found that the MOC-etomidate had an in-vitro half-life of 4.4 minutes versus more than 40 minutes for etomidate, and produced carboxylic acid as its only detectable metabolite MOC-etomidate is an etomidate analogue that retains etomidate's important favorable pharmacological properties 40% in etomidate vs 20%40% in etomidate vs. 20% pp[=.02 OR=3.86 [1.241.24--1 Longer stay p=.02 Fewer Days on Vent p=.04 2009 % in others% in others 2] tomidate What to expect Very rapid take down Microsoft PowerPoint - RSI Drugs Symposium 2012.ppt [Compatibility Mode] Author • Etomidate commonly used in RSI - Good effect and side-effect profile • Single doses of etomidate lead to with adrenal suppression in critically ill septicadrenal suppression in critically ill, septic patients - 77% vs 51% (p=0.008) • Etomidate associated with increased morbidity/mortality variably Baird Emerg Med J.2009; Mohammed. Etomidate Etomidate is a carboxylated imidazole derivative. Etomidate has anesthetic and amnetic properties, but has no analgesic properties Uses Etomidate is commonly used in the emergency setting as part of a rapid sequence induction to induce anesthesia or for conscious sedation Inotropic effects of propofol, thiopental, midazolam, etomidate and ketamine on isolated human atrial muscle Gelissen, Harry P et al, Anesthesiology 1996 At clinically relevant concentrations, etomidate has no inotropic negative effect, contrary to thiopental

Etomidate Etomidate is an imidazole ester. It is usually presented as a lipid emulsion or as a clear solution containing propylene glycol at a concentration of 2mg/ml. Pain on injection is common and there is a high rate of thrombophlebitis in the post operative period Side effects of etomidate, such as seizures, were recorded. Statistical analyses included Student's t -test and Fisher exact test; a P value less than 0.05 was defined for statistical significance. Data are presented as mean (SD) and count as appropriate. Patient characteristics and dosing data for etomidate are summarised in Table 1

Etomidate X X X Etoposide X X Phlebitis Grading Scale Fluorouracil X X Grade Clinical Criteria Gemcitabine X X 0 € No symptoms Gemtuzumab X X 1 € Erythema at access site +/- pain Idarubicin* X X 2 € Pain at access site with erythema +/- edema Ifosfamide X € Pain at access site with erythema +/- edema Iohexol* (see contrast agent. Provider Credentialing for Adult Procedural Sedation • To perform a procedure while supervising a nurse providing moderate sedation, a provider must meet the following criteria • Licensing and Training verification •Hold an unrestricted state license (MD, DO, DPM, DDS, PA or NP Introduction. Etomidate, an imidazole derivative, is a commonly used induction agent for emergency tracheal intubation, due to its favorable hemodynamic profile and the conditions it produces to facilitate intubation. 1-5 Despite these advantageous features, even a single dose of etomidate induces adrenal suppression. 6-10 It does this by interfering with the steroidogenic enzymes 11-β.

Times New Roman Comic Sans MS Default Design Adobe Photoshop Image Microsoft PowerPoint Presentation 2003-2004 Anaesthetics Review Alfentanil Chloral hydrate Enflurane Etomidate Halothane Isoflurane Ketamine Lidocaine Mepivacaine Nitrous oxide Procaine Propofol Sufentanil Tetracaine Thiopenta Drugs Used for General Anesthesia #1. Barbiturates and similar agents: Methohexital; etomidate; propofol. Benzodiazepines: midazolam-a short-acting benzodiazepine CNS depressant, is used as a preanesthetic drug to relieve anxiety (not prevent vomiting); for induction of anesthesia; for conscious sedation before minor procedures, such as endoscopy; and to supplement nitrous oxide and oxygen for. Start studying IV induction agents PPT. Learn vocabulary, terms, and more with flashcards, games, and other study tools thetics (ketamine),30 and nonbarbiturate sedatives (etomidate,31 propofol,32 and the benzodiazepines).21,33 The dosages and characteristics of these agents and are sum-marized in Table 1. One caveat to remember is that the induction dosages of these sedatives may be different (generally, slightly higher) than the dose used for sedation

Etomidate - FDA prescribing information, side effects and use

Etomidate - drop in bp 17-23/6.5-10 (11-13) Not in ED, patients not in shock . Zed P, Laban R. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: an observational cohort study. Academic emergency medicin IV ketamine, etomidate and propofol have a more rapid onset of action than dexmedetomidine (1 to 2 minutes versus 8 to 16 minutes, respectively) and etomidate has a shorter duration of action than dexmedetomidine (approximately 15 minutes compared with 30 minutes, respectively) . Duration of action with ketamine and propofol varies by dose and. G e n e r a l P r o t o c o l s Pearls · Agencies must maintain a separate Performance Improvement Program specific to Rapid Sequence Intubation. · This protocol is only for use in patients with an Age 12 or greater or patients longer than the Broselow-Luten Tape. · Once a patient has been given a paralytic drug, YOU ARE RESPONSIBLE FOR VENTILATIONS if desaturation occurs Etomidate is a very effective drug in severe Cushing's syndrome that is refractory to ketoconazol. Control of the serum cortisol levels in ectopic Cushing's syndrome can be obtained with infusion rates much lower than those used in anesthesia, without respiratory side effects May 2005 Board PowerPoint! 8! Milwaukee Etomidate • has no hemodynamic effects • suppresses adrenal cortex for at least 1 day Plasma Cortisol Level (µg/dl) 0 20 40 60 pre induct CPB postop 24h Ketamine Etomidate J Cardiothor Vasc Anesth 1998; 12:182-5 Milwaukee Anatomy - Pulmonary Hypertension •11 m/o, 5kg boy, s/p TAPVR

There are a few induction agents, but the big ones to consider are etomidate, ketamine, and propofol. Etomidate: 0.3 mg/kg IV, quick onset, lasts 3-12 minutes. Has a long history of use in RSI and is a common go-to choice. There is some concern that it may cause adrenal suppression in septic patients, but this is up for debate If we deem that intubation is still necessary at this point, we can proceed with standard RSI by administering a conventional sedation agent (e.g. etomidate or additional ketamine) in combination with a paralytic, as the patient has already been appropriately preoxygenated Ketamine may be used if etomidate is unavailable, and may be pre-ferred for patients who have hypotension or possible hypovolemia, or if ventilatory difficulty is thought to be the result of pain response. Dose: Administer 2 mg/kg IVP over 60 seconds Etomidate, an imidazole-derived ultrashort-acting nonbarbiturate hypnotic, is frequently used to induce anesthesia in critically ill patients because of its favorable hemodynamic profile and rapid onset. Etomidate has the advantage of minimizing induction hypotension which can cause coronary hypoperfusion, dysrhythmia, and cardiac arrest

ETOMIDATE rapid induction minimal change in cardiac function minimal change in respiratory rate not analgesic cause pain and myoclonus on injection and nausea postoperatively Prolonged administration may cause adrenal suppression. www.medicalppt.blogspot.com for more lectures www.medicalppt.blogspot.com for more lecture Anesthetic Implications of Myasthenia Gravis M ARK A BEL , M.D. 1,AND JAMES B. E ISENKRAFT , M.D. 2 Abstract Myasthenia gravis is a disease of great significance to the anesthesiologist, because it affects the neuro The effect of single-dose etomidate on mortality in patients with sepsis remains controversial. We systematically reviewed the literature to investigate whether a single dose of etomidate for rapid sequence intubation increased mortality in patients with sepsis

Etomidate - Wikipedi

Rapid Sequence Intubation Indications for RSI Oxygenation failure PaO 2 less than 60 on FiO 2 greater than 40 % Ventilation failure pCO 2 greater than 55 with previously normal pCO 2 or acute rise of 10 or more torr Need hyperventilation Profound shock Reduces energy expenditure used during rapid breathin Etomidate is known for its cardiovascular stability in comparison with propofol and thiopental. At induction dose of 0.3 mg kg −1, etomidate has no effect on systemic vascular resistance, myocardial contractility, and heart rate. Respiratory. Etomidate has minimal effect on ventilation and does not cause apnoea at appropriate clinical doses. T MF, Brock-Utne JG, Bean P, et al. Anaesthesia and intra-ocular pressure: a comparative of total intravenous anaesthesia using etomidate with conventional inhalation anaesthesia. Anaesthesia 1982; 37:758. Berry JM, Merin RG. Etomidate myoclonus and the open globe. Anesth Analg 1989; 69:256. Sinha A, Baumann BC. Anesthesia for ocular trauma Etomidate (0.3 mg/kg IV push) is recommended for induction because of its minimal effect on blood pressure and intracranial pressure. Ketamine is usually discouraged for RSI because it.. In this subset of patients, adrenal insufficiency was found in 86% of the etomidate group compared with 48% of the ketamine group, with 28-day mortality rates of 44/142 (31%) for non-responders and 19/90 (21%) for responders (p=0·11). Download .PPT; Linked Articles

Ppt. HAD - SlideShar

  1. The use of single-dose etomidate to facilitate intubation in critically ill patients has recently been debated given its suppression of steroidogenesis with possible resultant adverse outcomes. Our objective was to assess the effects of single-dose etomidate used during rapid-sequence intubation (RSI) on various measures of outcome, such as mortality, vasopressor use, corticosteroid use, ICU.
  2. Pour plus de modèles : Modèles Powerpoint PPT gratuits Page 1 ANESTHÉSIQUES GÉNÉRAUX ET LOCAUX Faculté de Médecine d'Annaba Département de Pharmacie Laboratoire de Pharmacologie Barbituriques, Midazolam, Etomidate, Propofol. MÉCANISME D'ACTION DES ANESTHÉSIQUES GÉNÉRAUX (AG
  3. obutyric acid (GABA)-mediated sedative hypnotic. It has very potent sedative features, but no analgesic properties. One key feature is its very

Clinical and Molecular Pharmacology of Etomidate

A, etomidate is a carboxylated imidazole, (α-ethylbenzyl)-imidazole-5-carboxylate, and exists as two mirror image enantiomers. The asymmetric carbon atom is marked by an asterisk. R(+) etomidate is the isomer that is used clinically. The acyl azide derivative of etomidate is created by replacement of the ethoxy group with an azide group, N 3 Contrary to the primary findings of our review, a retrospective review of 327 rapid sequence intubation intubations using etomidate with rocuronium or succinylcholine in the emergency department showed equivalent success at first intubation attempts 69. Median doses of rocuronium were 1.19 mg.kg −1 and 1.5 mg.kg −1 of succinylcholine Rapid sequence intubation (RSI) is an airway management technique that produces inducing immediate unresponsiveness (induction agent) and muscular relaxation (neuromuscular blocking agent) and is the fastest and most effective means of controlling the emergency airwa Etomidate causes least haemodynamic changes. Ketamine should be avoided, as it increases the systemic vascular resistance (SVR). Although propofol has a negative inotropic effect, it is useful in reducing the SVR. All volatile anaesthetic agents cause myocardial depression in high concentration Order of Drug Administration During Rapid Sequence Intubation with Etomidate May Not Matter Lauren M. Westafer, DO, MPH, MS , reviewing Driver BE et al. Acad Emerg Med 2019 Mar 4 This secondary analysis of emergency department RSI found no association between drug order and apnea time but is not generalizable to sedatives other than etomidate

Etomidate is currently the only pharmacological agent which can is given intravenously. It has a rapid time of onset and generally requires monitoring in an intensive care unit . Etomidate is the drug of choice for acutely unwell patients with severe hypercortisolism who are not medically safe for imminent surgery 234 patients were analysed in the etomidate group and 235 in the ketamine group. The mean maximum SOFA score between the two groups did not differ significantly (10·3 [SD 3·7] for etomidate vs 9·6 [3·9] for ketamine; mean difference 0·7 [95% CI 0·0-1·4], p=0·056). Intubation conditions did not differ significantly between the two groups (median intubation difficulty score 1 [IQR 0. Etomidate is an imidazole derivative dosed at 0.3 mg/kg IV; the time of onset is 15-30 seconds, and the duration of action is approximately 3-12 minutes. 1 Its minimal effects on blood pressure and heart rate, combined with its rapid onset, makes this drug safe in most RSI situations. 8 Etomidate may have deleterious effects in two disease. Dosage of Etomidate ranged from 8 mg to 40 mg with an average of 26 mg . The dose did not correlate with success or failure of the drug in this data review. Title: Microsoft PowerPoint - Etomidate Usage Author: E . James Radin Created Date

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Etomidate: cortical SEP amplitude augmented 200-600%, increases SEP latencies - Opiates, cause a slight increase in SEP latency - Muscle . relaxants, notaffect SEPs. PowerPoint Presentation Last modified by: abbie whited. Etomidate (second line) .3mg/kg IV/IO 4. Neuromuscular blockade - Succinylcholine 1.5mg/kg IV/IO (2mg/kg <5 years old) or Rocuronium 1mg/kg IV/IO Avoid surgical airway in <12 years old - use needle cricothyroidotomy (12-14 gauge), tracheostomy preferred over surgical cricothyroidotomy.

Short period of deep sedation/general anesthesia, usually using bolus dose of propofol/etomidate depending on ejection fraction. A soft bite block should be placed. Transesophageal. Echocardiograms (~ 60 minutes Etomidate is a hypnotic nonbarbiturate, ultra-short-acting anesthetic agent associated with involuntary muscle movements in 10-70% of patients. These movements can be violent and mimic seizure activity. Etomidate is often administered because of its cardiovascular stabilizing effect Etomidate (0.3mg/kg) also has very limited haemodynamic effects. Use has been limited by concerns of adrenal suppression, and there is limited availability in some countries. Thiopentone (3-5mg/kg) has the most rapid and predictable effect, with less haemodynamic instability than propofol. However, there may be issues with poor availability and.

Iv anaesthetics

Etomidate: Indications, Side Effects, Warnings - Drugs

The γ-aminobutyric acid type A (GABAA) receptor is a transmitter-gated ion channel mediating the majority of fast inhibitory synaptic transmission within the brain. The receptor is a pentameric assembly of subunits drawn from multiple classes (α1-6, β1-3, γ1-3, δ1, and ɛ1). Positive allosteric modulation of GABAA receptor activity by general anesthetics represents one logical. Etomidate is a widely used intravenous induction agent that is especially useful for patients at risk for hypotension during anesthesia induction. Side effects limiting its use include adrenocortical suppression, acidosis, myoclonus, venous irritation, and phlebitis drugs (thiopental>>ketamine, propofol>etomidate)— become increasingly evident with prolonged IV infu-sions, or large cumulative doses. A short duration of action depends on redistribution, which is saturable and limited by the mass of lean tissue. Pharmacoki-netic modeling has led to pharmacokinetic/pharma For intubation, we combine Succ with Etomidate pre-intubation as a 2 drug combo. For procedures, Etomidate is short acting with the patient waking back up in minutes rather than hours and discharges are more expedient after the required monitoring time and without many residual side effects. Powerpoint on Adrenal Suppression from Etomidate.

Intravenous Etomidate for Procedural Sedation in Emergency

-Etomidate, Midazolam, Fentanyl, Propofol, Precedex •Neuromuscular blocking agents -Rocuronium, succinylcholine, cisatracurium •Treat hypotension -IV bolus -Vasopressor infusion •Epinephrine, Dopamine, Norepinephrine. 18. 19 Code Blue: Patient Case 1 Diabetes, Hypertension, Renal disease o Etomidate can be safely administered to adults for procedural sedation and analgesia in the ED. A combination of propofol and ketamine can be safely administered to children and adults for procedural sedation and analgesia Page 1 1. Introduction and scope Forced degradation is an exposure of the drug substance or drug product to different stress conditions (more severe than accelerated conditions) [1] which results in relevan

Etomidate for short pediatric procedures in the emergency

An antidote is a substance that can counteract a form of poisoning. The term antidote is a Greek word meaning given against. This post will help you familiarize yourself with the common antidotes that are used in the hospital setting. The following are antidotes that should be familiarized by the nurse to respond to this emergency situation quickly Non-Gap Metabolic Acidosis. Treatment pH < 7.1 Discontinue any suspected drugs IV fluids Calculate bicarbonate deficit (0.5L/kg x Weight (kg) x [HCO 3] desired - [HCO 3] observed Give 30-50 % of calculated dose over 30 minutes to several hours Reassess need for additional replacement with ABG 3 Etomidate is close toan ideal anesthetic except for its well-known side effect of adrenocortical suppression. Derivatives of etomidate are in review currently that seek to eliminate this side effect while maintaining the efficacy of etomidate. Gantacurium is a new non-depolarizing agent PowerPoint Presentation Author

Procedural Sedation: Overview, Sedation Definitions

Laminectomy was performed to record single unit activity. Lumbar neuronal responses to noxious thermal stimulation of the hindpaw were recorded before and every 2 minutes after administration of etomidate. The responses at peak effect of etomidate were reduced to 36% of the control response, depending on the dose (0.125, 0.25, 0.5, 1, and 2 mg/kg) Thiopentone As Induction Agent (etomidate) Rsi. Ob And Cardiothoracic. Nmb, Esp PPT. Presentation Summary : Thiopentone as induction agent (etomidate) RSI. OB and cardiothoracic. NMB, esp with no monitoring or reversal. Focus on. Phases of anaesthesia. TIVA/TCI. DOA

PPT - Pre-hospital Rapid Sequence Intubation PowerPoint

Pediatric Procedural Sedation - Emergency Medicine Case

Etomidate ↑ ↔ Ketamine ↑ ↔ Midazolam ↓ ↔ Opioids ↔ ↔ Propofol ↔ ↔ C. Surgical Distraction of the Spine 1. After surgical exposure and placement of anchoring hardware the surgeon will begin to distract, or straighten, the spine. This is a high-risk time for neurophysiologic compromise. The surgeon should notify th Etomidate has a potential cerebroprotective effect as it decreases cerebral metabolic oxygen consumption and reduces cerebral blood flow and intracranial hypertension while maintaining cerebral perfusion pressure Side effects are nausea, vomiting, myoclonus and adrenal cortical depression with multiple doses

Etomidate Use Is Associated With Less Hypotension Than

Etomidate is approximately 100-fold more potent a suppressor of adrenocortical function than it is a sedative-hypnotic The locus coeruleus (LC)-norepinephrine (NE) system is involved in general anesthesia. Here, Du et al. show that the LC-NE system plays a modulatory role in the induction and emergence of intravenous general anesthesia induced by propofol and etomidate, both of which suppress LC neuronal activities through a cooperative mechanism Midazolam vs Etomidate vs Propofol 32 cardioversions All 3 worked well Longer recovery time with midazolam (21 vs 8 mins) 4/9 Etomidate pts had myoclonus Propofol vs Methohexital: Miner J, Acad Emerg Med, 2003: 103 pts, randomized 1 mg/kg, 0.5 mg/kg No diff in resp depression: 48% Bagging: 4% vs 8% No hypotensio Photoreactive derivatives of the general anesthetic etomidate have been developed to identify their binding sites in γ-aminobutyric acid, type A and nicotinic acetylcholine receptors. One such drug, [3H]TDBzl-etomidate (4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl-[3H]1-(1-phenylethyl)-1H-imidazole-5-carboxylate), acts as a positive allosteric potentiator of Torpedo nACh receptor (nAChR. The effects of anesthesia with etomidate on the cellular mechanisms of sensory processing and sensorimotor coordination have been studied in the active electric sense of the mormyrid fish Gnathonemus petersii.Like many anesthetics, etomidate is known to potentiate GABA A receptors, but little is known about the effects on sensory processing at the systems level

PPT - Procedural Sedation in the Pre-Hospital SettingPPT - Analgésie-sédation du patient polytraumatisé en

Etomidate at a clinically relevant concentration (3.2 μ M) enhances maximal response without altering the EC50 of GABA concentration response. Etomidate also increases the extent of desensitization and prolongs the deactivation of α 4 β 3 δ receptors in the presence of maximally activating concentrations of GABA (1 mM) Pulmonary hypertension is a major reason for elevated perioperative morbidity and mortality, even in noncardiac surgical procedures. Patients should be thoroughly prepared for the intervention and allowed plenty of time for consideration. All specialty units involved in treatment should play a role in these preparations. After selecting each of the suitable individual anesthetic and surgical. Uses Anesthesia. Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia.Its use has been largely replaced with that of propofol, but may retain some popularity as an induction agent for rapid-sequence induction and intubation, such as in obstetrics. [citation needed] Following intravenous injection, the drug rapidly. Kropf JA, Grossman MA, et al. Ketamine versus Etomidate for Rapid Sequence Intubation in Traumatically Injured Patients: An Exploratory Study. Annals of Emergency Medicine . 2012. Volume 60, Issue.

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